Neuroinflammation and сhemotherapy-induced peripheral neuropathy
نویسندگان
چکیده
Neurotoxicity is one of the common side effects anticancer chemotherapy. This pathology has a detectability 38–90%. In some cases, it causes not only significant decrease life quality but also dose cytostatics. Therefore, tasks early diagnosis, prevention and treatment neurotoxicity are very relevant. Sensors underlying detection, especially neuroinflammation processes, needed to develop an effective therapy for chemotherapy-induced neurotoxicity. The purpose this topic study results chemotherapy studies on changes in activity proinflammatory cytokines. regard, behavioral societies neuropathic pain animal models great importance. It was revealed that various manifestations inflammation pro-inflammatory cytokines, chemokines, damage dorsal ganglion or distal nerve endings increasingly being detected. Detection chemically induced peripheral neuropathy using necessary in-depth identification cause-and-effect mechanisms its development selection new, more methods treatment.
منابع مشابه
Chemotherapy-induced peripheral neuropathy.
PURPOSE/OBJECTIVES To review the literature documenting the scope, treatment, and prevention of chemotherapy-induced neuropathy. DATA SOURCES Published abstracts, primary research literature, and textbook chapters. DATA SYNTHESIS Recent improvements in the management of other treatment-related toxicities have led to peripheral neuropathy becoming a dose-limiting toxicity of commonly used ch...
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ژورنال
عنوان ژورنال: Sibirskij nau?nyj medicinskij žurnal
سال: 2022
ISSN: ['2410-2512', '2410-2520']
DOI: https://doi.org/10.18699/ssmj20220201